The faith community of Holy Spirit began in 1973 when a small group of worshippers began meeting in a private garage. Holy Spirit Parish was established in May 1975 as a mission of Our Lady of the Valley Parish. For several months, Mass was celebrated in various places including a sales office and a fire station in Horizon City.
As the congregation continued to grow, the community bought a small home on McMahon and Acra Streets which was remodeled into a church and consecrated by Bishop Metzger in 1976. The first Mass was held in what is now a meeting room of the rectory.
Soon, the church purchased the lot across the street and in January 1979, Bishop Flores authorized the building of a new church on the property. In 1980, the church was completed.
In 2001, expansion on the building was completed when the worship space was enlarged and two halls and three classrooms were added. In 2008, Holy Spirit proudly celebrated its 35th Anniversary as a faith community.
The church has been served by various priests including the Reverends Jose Frank, Thomas Rowland, Trini Fuentes, Miguel Alcuino, Rick Matty, Joe Molina, Marcus McFadin, Ralph Solis and Pablo Matta. On November 8, 2013, Father Jose Morales was appointed administrator of, then, Holy Spirit Mission, which was under the care of Frances Xavier Cabrini Parish.
On December 24, 2014 Most Rev. Mark J. Seitz named Holy Spirit a Parish being Rev. Jose A. Morales assigned as its first pastor. At that time it was also determined that Holy Spirit Parish would have under its care El Buen Pastor Mission in Sparks, La Resurreccion Mission in El Paso Hills and Centro Juan Diego in Agua Dulce.
On July of 2015, a new administrator was named for El Buen Pastor Mission in Sparks and La Resurreccion Mission in El Paso Hills.
Today, Holy Spirit serves 850 families and prepares 200 children each year for First Holy Communion and Confirmation. The church also ministers to Centro Juan Diego Catechetical Canter in the Agua Dulce Colonia.
On February 2, 2019, the Feast of the Presentation of the Lord a Mass was celebrated on the new property to mark the beginning of the construction of the new facilities. The building project is the first of three phases and it entails a multipurpose building. This multipurpose building houses the administrative area, common area, kitchen, and a temporary worship space. The construction is schedule to be completed in July of 2020.